After the devastating events of Seraph of the End: Catastrophe at Sixteen, Guren Ichinose finds himself haunted by the consequences of his actions. By breaking the sacred law against human resurrection to bring his friends back, Guren has triggered the downfall of humanity. The Seraph of the End, a force of unimaginable power, has left the world in ruins, where the last vestiges of human life are scattered and broken.

Now, only demons and children survive amidst the chaos, with humans hunted and herded like livestock by ruthless vampires. Facing an apocalyptic world, the few remaining survivors cling to the faint hope of restoring what was lost. Guren, burdened by guilt and unable to confide in anyone, sets out on a solitary path through the shattered remnants of the world he once knew.

Torn between his humanity and the growing darkness inside him, Guren wrestles with his identity. Is he still human, or has he become something darker? Savior or executioner, hero or harbinger of death—his fate remains uncertain. Guren embarks on a quest, uncertain whether he will save the world or lead it to further ruin.